Queensland medical researchers, as part of an international study, have found a variant in the MITF gene which can significantly increase the risk of melanoma. The MITF gene is responsible for regulating pigmentation and melanoma development, but this small mutation can have a large impact on melanoma risk. Individuals possessing this genetic variant have a 250% increased risk of developing melanoma – which is as significant to melanoma risk as traits such as having red hair, say the researchers.
Dr Stuart MacGregor, Queensland Institute of Medical Research
Nature