Embargo: 1 am AEST Tuesday 29 April 2014
Published in Nature Structural and Molecular Biology
Australian, US and Dutch researchers have determined the molecular details of the interaction between the immune system and gluten that triggers celiac disease. Their work opens the way to potential treatments and diagnostics.
Monash, Melbourne and Leiden university researchers, in collaboration with colleagues from a Boston-based company, have described the molecular basis of how most of the immune cells (T cells) that induce celiac disease lock onto gliadin, a component of gluten, thereby triggering inflammation of the lining of the small intestine. This is what gives many celiac sufferers symptoms similar to food poisoning after eating a slice of toast. [continue reading…]