Head to tail: the molecules that tell you how to grow a backbone
Growing the right number of vertebrae in the right places is an important job – and scientists have found the molecules that act like ‘theatre directors’ for vertebrae genes in mice: telling them how much or how little to express themselves.
The finding may give insight into how the body-shapes of different species of animals evolved, since the molecules under scrutiny are present in a wide range of animals – from fish to snakes to humans.
An international team led by Dr Edwina McGlinn of EMBL Australia [1] at Monash University found that de-activating a small group of microRNA (miRNA) molecules sent things awry for different parts of the backbone.
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