Clinical and Health Sciences

Slipped discs: robot shows it’s not all bending and twisting

High res photos available below.

Video of Dhara and the bending robot available here.

Dhara hopes her work will lead to improved guidelines on repetitive and heavy lifting. Credit: Flinders University

Some slipped disc injuries might be caused by movements other than the commonly blamed bending and twisting, according to new research by South Australian engineers.

It’s a finding that will lead to a better understanding of the motions that put people at greatest risk of a slipped disc and help develop more robust guidelines for safe lifting.

Kid-friendly chocolate formula helps the medicine go down

FOR VIDEO AND IMAGES CLICK HERE

Researchers from The University of Western Australia have developed a winning medicine formula that makes bad-tasting medicine taste nice, making it easier to treat sick children.

The UWA study published by the journal Anaesthesia tested 150 children and found that the majority of children who were given the new chocolate-tasting medicine would take it again, unlike the standard treatment, while they still experienced the same beneficial effects.

UWA Clinical Senior Lecturer Dr Sam Salman said the poor taste of many medicines, such as Midazolam, a sedative used prior to surgery, presented a real difficulty in effectively treating children.

When will stem cells save more lives?

Melissa Little and her colleagues worked for six years to bring the world’s largest stem cell meeting to Melbourne this week.

What did she learn? What are the next big steps should we should be watching for in curing diseases and saving lives with stem cells?

Melissa can also talk about her own research at the Murdoch Children’s Research Institute. She’s made mini-kidneys that are a step towards stopping a silent killer, chronic kidney disease.

The International Society for Stem Cell Research 2018 Annual Meeting closes today. 2,500+ stem cell scientists from 53 countries heard from 150+ speakers.

Treating haemophilia and eye disease with gene therapy

Katherine High (USA) will report today on an FDA approved gene therapy for a form of blindness, and on a clinical trial in people with haemophilia. [Read more…] about When will stem cells save more lives?

Manufacturing a cell therapy peace-keeping force, and more

20-23 June 2018 at the Melbourne Convention and Exhibition Centre

International Society for Stem Cell Research 2018 Annual Meeting: 2,500+ stem cell scientists from 50 countries will hear from 150+ speakers including:

Lab-grown mini-brains make new connections

Fred ‘Rusty’ Gage (USA) is making mini-brains from human stem cells in the lab. But in order for these new tissues to function, they need to become well-connected.

Fred is pioneering research to explore how transplanted human neural organoids (mini-organs) can mature into tissues with blood vessel and nerve connections. This work could lead to methods of replacing brain tissue lost to stroke or disease, and repairing spinal cords damaged by trauma.

Tracing blood back to its beginnings to tackle leukaemia

Right now, the stem cells in your bone marrow are making one billion new red blood cells per minute. Andrew Elefanty (Australia) is studying both embryonic stem cells and more specialised blood-forming stem cells to reveal how our body makes blood and what leads to leukaemia and other blood diseases. He will reveal his team’s latest insights. [Read more…] about Manufacturing a cell therapy peace-keeping force, and more

Treating diabetes; turning skin cells into brain cells; hearts in a dish

20-23 June 2018 at the Melbourne Convention and Exhibition Centre

International Society for Stem Cell Research 2018 Annual Meeting: 2,500+ stem cell scientists from 50 countries will hear from 150+ speakers including:

Treating type 1 diabetes with stem cells

A Harvard team has shown they can control glucose levels in mice using a transplant of insulin-producing cells made from human stem cells. Doug Melton presents his research today.

His effort to fight diabetes involves a 30-person lab at Harvard and a start-up company, Semma Therapeutics, which he named after his children. His son Sam and daughter Emma both have type 1 diabetes.

Skin cells become brain cells to solve a mystery

Queensland researchers have taken skin cells from a young patient with a rare genetic brain condition and turned them into stem cells that are coaxed to become brain cells. Massimo Damiani has now passed away, but his legacy of growing brain cells in the lab could help others with this rare condition.

Hearts in a dish helping personalised medicine

Christine Mummery and her Dutch research team have discovered that heart cells made from patient stem cells with known mutations predicted the electrical heart problems and drug sensitivities observed in the patients themselves.

Christine is co-author of the book Stem Cells: Scientific Facts and Fiction.

Could you regrow an arm or a leg? Salamanders can.

Could you regrow an arm or a leg? Salamanders can.
Should you be allowed to try unapproved treatments without the FDA tick when you’re terminally ill? President Trump says yes.

20-23 June 2018 at the Melbourne Convention and Exhibition Centre

International Society for Stem Cell Research 2018 Annual Meeting: more than 2,500 stem cell scientists from 50 countries will hear from 150+ speakers, including:

Taking stem cell science from the lab to the clinic, and what’s wrong with the US ‘right to try’ legislation—Roger Barker, UK

Smart socks help physiotherapists treat patients remotely

‘Smart socks’ are helping physiotherapists better assess and treat patients during video consultations, by providing information on weight distribution and range of movement during exercises like steps, squats or jumps.

The wearable technology, developed by PhD candidate Deepti Aggarwal at The University of Melbourne, was trialled with three patients and a physiotherapist at the Royal Children’s Hospital, from February to June 2017.

Background images and video below.

New rotavirus vaccine could benefit millions of children

A rotavirus vaccine that can be given days after birth has been developed by Australian and Indonesian researchers.

Rotavirus is the common cause of severe diarrhoea and a killer of approximately 215,000 children under five globally each year.

The oral vaccine, called RV3-BB, was given in three single doses, the first within five days of birth. Until now, the vaccine against rotavirus was available in Australia and only on the private market in Indonesia, and could only be administered from six weeks of age.

After three doses of RV3-BB administered from birth:

94 per cent of infants were protected in their first year of life against severe rotavirus gastroenteritis
75 per cent of infants were protected to 18 months of age.

The success of the RV3-BB vaccine is the culmination of more than four decades of work, which started with the Murdoch Children’s Research Institute’s Professor Ruth Bishop and the discovery of rotavirus in 1973.

The trial was funded by the National Health and Medical Research Council (NHMRC), Bill & Melinda Gates Foundation and PT BioFarma.

Read the full media release on the MCRI website.

Read an earlier story on the work in our Stories of Indonesia-Australia Innovation collection from 2016.

Detecting high risk pregnancies in Indonesia

Women in Indonesia were 21 times more likely to die from childbirth than women in Australia in 2015. Many pregnant women in Indonesia, particularly in remote areas, do not regularly visit health clinics and so complications are not detected and dealt with early enough.

Indonesian and Australian scientists test new TB vaccine targets for the TB fight in Indonesia and Australia

World TB Day on March 24 reminds us of the growing TB threat

Scientists available for interview in English and Bahasa Indonesia for World TB Day. Read the release in Bahasa Indonesia.
More images below.

Better vaccines are needed for the global fight against tuberculosis (TB). The Global Fund reports an estimated nine million new cases globally per year of TB, which is second only to AIDS as the world’s most deadly infectious disease. Indonesia had more than 320,000 reported cases in 2014 according to the World Health Organization, while Australia’s reported cases were just over 1,000. But the rise of drug-resistant TB poses a threat to all countries.

Two proteins from the tuberculosis bacterium have shown promising results in investigations in mice for a new vaccine. Scientists from the Centenary Institute and the University of Sydney, with colleagues at Universitas Gadjah Mada (UGM) in Yogyakarta, have found that the injected proteins can prime the immune system to induce protection against TB in mice.

The team has established a laboratory and immunological techniques to test if the two proteins from the tuberculosis bacterium can be used as the basis for a vaccine. Credit: Centenary Institute

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Clinical and Health Sciences

Treating haemophilia and eye disease with gene therapy

20-23 June 2018 at the Melbourne Convention and Exhibition Centre

Lab-grown mini-brains make new connections

Tracing blood back to its beginnings to tackle leukaemia

20-23 June 2018 at the Melbourne Convention and Exhibition Centre

Treating type 1 diabetes with stem cells

Skin cells become brain cells to solve a mystery

Hearts in a dish helping personalised medicine

20-23 June 2018 at the Melbourne Convention and Exhibition Centre

Taking stem cell science from the lab to the clinic, and what’s wrong with the US ‘right to try’ legislation—Roger Barker, UK

‘Smart socks’ are helping physiotherapists better assess and treat patients during video consultations, by providing information on weight distribution and range of movement during exercises like steps, squats or jumps.

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