Melbourne Children’s Global Health is an initiative to improve the health of children and adolescents in disadvantaged populations globally through partnerships in research, public health, education and advocacy.

The initiative has been created by Murdoch Children’s Research Institute, the University of Melbourne Department of Paediatrics, and the Royal Children’s Hospital under the auspices of the Melbourne Children’s Campus, and with the support of the Royal Children’s Hospital Foundation.

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The first baby in Indonesia to be vaccinated with the new vaccine. (Credit: Melbourne Children’s Campus)

The midwives and doctor at the Jatinom Primary Health Centre in Klaten District, Central Java, which is connected to the new rotavirus trial. (Credit: Melbourne Children’s Campus)

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Bio Farma, Indonesia’s national vaccine company, is completing a phase 1 trial of a new rotavirus vaccine invented in Melbourne and has started pilot manufacture of the vaccine. Licencing trials are next, followed hopefully by release of the new vaccine in 2021.

The project is the culmination of a 42-year partnership between Melbourne and Gadjah Mada University which started after Ruth Bishop and colleagues found a virus, now known as rotavirus, in babies at the Royal Children’s Hospital in Melbourne. They showed it was the cause of an acute gastroenteritis that was hospitalising 10,000 Australian children every year and killing more than half a million children worldwide. [continue reading…]

In 2017, almost one million children fell ill and over 200,000 children under 15 died of tuberculosis, according to the latest WHO Roadmap. The report also identifies a previously underreported challenge, TB in adolescents.

University of Melbourne researcher Ms Kathryn Snow has estimated that about 1.8 million young people develop TB every year comprising [continue reading…]

Scientists use computer simulations of joint and muscle movements to teach us to exercise smarter

Image: Dr Pizzolato is making digital twins to help improve how people move in real life. Credit: Gold Coast Orthopaedic Research Alliance, Griffith University

Researchers have developed computer simulations of joint and muscle movements that can teach us how to exercise smarter and prevent knee pain and further damage.

One in five Australians over the age of 45 suffer from painful and debilitating osteoarthritis, with the knee being the most commonly affected joint.  

Dr Claudio Pizzolato from Griffith University is making computer avatars or ‘digital twins’ of individual patients to see how their muscles and joints work. [continue reading…]

Macquarie University and UWA scientists will join forces with two Australian companies to search for new antibiotics in 500,000 species of Australian microbes.

Background information below.

The project will be supported by a $3 million CRC-P grant announced by Australia’s Assistant Minister for Science, Jobs and Innovation, Senator Zed Seselja.

“We have samples of over 500,000 Australian microbes,” says Dr Ernest Lacey, Managing Director of Sydney-based company, Microbial Screening Technologies (MST), and the leader of the project.

Microbe-covered plates. Image credit: Andrew Piggott

“We’ve collected them from the soil in backyards, in paddocks, and forests. We’ve collected them from insects, plants and animals. We’ve gone everywhere to find Australia’s unique microbiome.”

“Each microbe contains a unique cocktail of metabolites. When we find an interesting new molecule, we’ll be relying on Macquarie University researcher Dr Andrew Piggott and his team to help us to work out its structure and mode of action.”

“Then Dr Heng Chooi from UWA will use genomics to unravel how the microbes assemble these metabolites and then boost their productivity.”

“Advanced Veterinary Therapeutics (AVT) is led by Dr Stephen Page and will focus on animal health potential,” says Dr Lacey.

“The CRC-P Program helps businesses, industries and research organisations to work together on short-term projects to develop practical solutions to challenges in key industry sectors,” Assistant Minister Seselja said at the project launch.

The three-year project, “BioAustralis, towards the future”, will harness MST’s unique collection as a source of next-generation antibiotics capable of overcoming microbial resistance. [continue reading…]

Mending broken hearts and burnt eyes, and much more

• Stem cells are saving lives today—through bone marrow and cord blood transplants
• There are trials making new skin, restoring sight, treating diabetes, repairing the brain
• But we’ll also hear of the dangers of risky treatments, snake oil merchants, and new Australian and US regulations.

More than 2,500 stem cell scientists from 50 countries are in Melbourne this week for the massive International Society for Stem Cell Research 2018 Annual Meeting. It’s taking place from 20-23 June at the Melbourne Convention and Exhibition Centre. Here are some highlights and we’ll have daily alerts for you with more people and ideas through the week.

Media are welcome.

Developing a stem cell product to cure blindness from burning—Michele De Luca and Graziella Pellegrini, Italy

Italian innovators Graziella Pellegrini and Michele De Luca have seen their work lead to patients regaining eyesight after 20 years of blindness. And it’s led to the world’s first non-blood-related commercial stem cell therapy.

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Female scientists have played a critical role in many scientific discoveries throughout history, but their contributions have often been overlooked.

Ahead of International Women’s Day this Thursday, Macquarie University scientists are celebrating the work of forgotten women of science through history; explaining how their work today is changing the world; and making the case for why women in earth and environmental sciences need to stand together.

• Lesley Hughes researches the impacts of climate change on species and ecosystems. Now she’s celebrating the work of Beatrix Potter and other pioneering but forgotten women of science, through the exhibition Hidden Figures of STEMM.
• Evolutionary biologist Jemma Geoghegan is using whales and fish to better understand how new viruses emerge.
• Kira Westaway uses glowing grains of sand to travel back in time. Her work has transformed our understanding of human evolution.
• Volcanologist Heather Handley’s research into volcanoes in the Pacific ‘Ring of Fire’ is improving our understanding of volcanic hazards. She’s also the co-founder and chair of new network Women in Earth and Environmental Sciences Australasia (WOMESSA).

More on each of these stories  below.

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