immunology

How superbug A. baumannii survives metal stress and resists antibiotics

Work is underway into how science can stop the superbug A. baumanniii after research exposes a weak link in the deadly but poorly understood pathogen.

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The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body’s built-in infection-fighting response. The World Health Organization (WHO) recognises it as one of the three top pathogens in critical need of new antibiotic therapies.

Now, an international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator. When the protein is damaged, the bug loses its superpowers allowing it to be controlled, in a lab setting. The research is published in Nucleic Acids Research.

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JABBED: a public forum on love, fear and vaccines

Public forum Wednesday, 5 June 2013

Diseases that were largely eradicated forty years ago are returning. Across the world children are getting sick and dying from preventable conditions because nervous parents are skipping their children’s shots.

Yet the stories of vaccine reactions are frightening, with cases of people being damaged, even killed, by vaccines. How do we decide whether to vaccinate or not, and what are the real risks?

  • Why are Melbourne babies getting whooping cough?
  • Why are measles epidemics appearing in Europe?
  • Why does vaccination remain so controversial?
  • While more than 90% of Australians support vaccination, why are many of us delaying or refusing vaccines?
  • What’s going wrong with the community conversation about vaccination?

Explore these issues and more at a public forum with Sonya Pemberton, the producer of JABBED, a documentary premiering on SBS TV on Sunday 26 May 2013. [continue reading…]

New immune cells hint at eczema cause

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Sydney researchers have discovered a new type of immune cell in skin that plays a role in fighting off parasitic invaders such as ticks, mites, and worms, and could be linked to eczema and allergic skin diseases.

The team from the Immune Imaging and T cell Laboratories at the Centenary Institute worked with colleagues from SA Pathology in Adelaide, the Malaghan Institute in Wellington, New Zealand and the USA.

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Keeping our best young bioscience brains in Australia: Centenary Institute Lawrence Creative Prize

The winner of the Centenary Institute Lawrence Creative Prize will be announced at 12.30 pm, Thursday 15 November 2012, at a lunch at UBS in Sydney.

He will receive $25,000, and a glass trophy designed by Australian sculptor Nick Mount.

The 2012 finalists are:

  • Robert McLaughlin, a medical engineer from the University of Western Australia (UWA), who has developed an optical probe that fits inside a hypodermic needle and can help surgeons accurately determine the boundaries of breast cancer tumours.
  • Marc Pellegrini, from Melbourne’s Walter and Eliza Hall Institute (WEHI), whose discoveries about how the body regulates its immune system are being applied to clinical trials of cancer vaccines and treatments for HIV and hepatitis.
  • Jian Yang, from the Diamantina Institute at the University of Queensland, who has solved a major puzzle of missing heritability by developing software and methods to determine the multiple genes involved in conditions such as schizophrenia, obesity and diabetes.

Immune peacekeepers discovered

How our skin says, “Don’t worry, these are good guys,” revealed today in PNAS.

There are more bacteria living on our skin and in our gut than cells in our body. We need them. But until now no-one knew how the immune system could tell that these bacteria are harmless.

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Lawrence Creative Prize finalists

The Centenary Institute Lawrence Creative Prize is a $25,000 award for outstanding creativity in biomedical research by young scientists.  Here are the three finalists.  The winner will be announced at an awards luncheon on Wednesday 19 October at the UBS dining room in Sydney.  For more information call Niall on 0417 131 977 or niall@scienceinpublic.com.au

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