Mystery of children’s ‘chalky teeth’ explained

A blood protein blocks hardening of enamel on teeth growing inside the jaw

Australian and Chilean researchers solve a 100-year-old mystery and call for education and research to save millions of teeth worldwide.

Case studies available.

One in five children have chalky tooth enamel – visible as discoloured enamel spots – which often causes severe toothache and decay, and sometimes leads to abscesses, extractions and orthodontic problems.

Now, researchers from The D3 Group (based at The University of Melbourne, Australia) and the University of Talca in Chile, have discovered the mechanism causing molar hypomineralisation, the commonest type of chalky teeth.

They report today in Frontiers of Physiology that chalky molars arise when developing enamel is contaminated by albumin – a protein found both in blood and in the tissue fluid surrounding developing teeth. The trigger appears to be childhood illnesses.

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New clues for allergy prevention by breast milk

Written by Akila Rekima and the University of Western Australia. For the full UWA press release, click here.

A research team at UWA is investigating the complex interactions of breast milk with allergens and baby’s gut immune system.

They’ve found that food-derived but also airborne allergens are present in breast milk. Some do give protection and reduce allergies later in life.

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One step closer to understanding cancer-fighting immune cells

Researchers discover that protective immune cells are not created equally 

Personalised treatment of cancers has moved one step closer, thanks to University of Melbourne researcher Dr Susan Christo.

Increasingly, cancers are being treated using an approach called immunotherapy – which uses a patient’s own immune cells to fight the disease.

However, challenges arise in so-called “solid cancers”, such as melanoma, where access may be limited so the cancer-fighting immune cells cannot penetrate the tumour site. 

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Whooping cough is fighting back.

Researchers discover how whooping cough is evolving paving the way to a new vaccine.

Whooping cough strains are adapting to better infect humans, a team of Sydney researchers has found.

The scientists, led by microbiologist Dr Laurence Luu of the University of New South Wales, may have solved the mystery of why, despite widespread vaccinations, the respiratory disease has been resurgent in Australia across the past decade. There have been more than 200,000 cases recorded during the period.

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Family matters in autism outcomes

Cognition is influenced by siblings, researchers find.

Autistic children with autistic siblings have better cognition than those who are the only family member with the condition, researchers have found.

Importantly, the outcome does not depend on birth order.

Although previous studies have identified that having autistic siblings leads to better cognition for individual children with the condition, it was assumed that the order in which the children were born was a significant factor.

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Sugar found to boost lethal bacteria

Adelaide researchers find how a bacteria digests a sugar can be key to new treatments

The severity of a common and often lethal type of bacteria depends on its ability to process a type of sugar, research from the University of Adelaide reveals.

Streptococcus pneumoniae causes diseases of the lungs, blood, ear and brain, killing an estimated one million people every year. Moreover S. pneumoniae causes otitis media (infection of the middle ear), which devastates Aboriginal populations. It also rapidly develops resistance to antibiotics, making it challenging to treat.

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Media Release: Melbourne steps up to drive global health

Images, video overlay, two case studies (rotavirus vaccine and TB in adolescents) and backgrounder available.

Melbourne Children’s Global Health initiative to take action for the:

  • Two million children dying annually from pneumonia and diarrhoea
  • 8 million new child and youth cases of TB each year
  • Mental health and wellbeing of youth caught up in global unemployment, civic unrest, conflict, urbanisation and migration
  • Hospitals and health workers who want training and education to help them save their young patients.

Three of Australia’s child health leaders are joining forces to tackle global child health. Melbourne Children’s Global Health will build on the achievements of the Murdoch Children’s Research Institute (MCRI), the Royal Children’s Hospital (RCH) and the University of Melbourne. Read More about Media Release: Melbourne steps up to drive global health

Images: Melbourne Global

For hi-res versions please click on the photo and then right click to download the file.

The first baby in Indonesia to be vaccinated with the new vaccine. (Credit: Melbourne Children’s Campus)

The midwives and doctor at the Jatinom Primary Health Centre in Klaten District, Central Java, which is connected to the new rotavirus trial. (Credit: Melbourne Children’s Campus)

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Case Study: TB in adolescents: Melbourne Children’s Global Health guides new WHO roadmap

In 2017, almost one million children fell ill and over 200,000 children under 15 died of tuberculosis, according to the latest WHO Roadmap. The report also identifies a previously underreported challenge, TB in adolescents.

University of Melbourne researcher Ms Kathryn Snow has estimated that about 1.8 million young people develop TB every year comprising Read More about Case Study: TB in adolescents: Melbourne Children’s Global Health guides new WHO roadmap